Classify Mutations as Silent, Missense or Nonsense
Written by Adi Ackerman, Head Teacher
"Classify Mutations as Silent, Missense or Nonsense" is written for 8th Grade (Ages 13-14), and it covers NGSS MS-LS3-1. A 7th grader who is already steady on living things can use it too, and an older student can use it as a short review.


2 pages in this set
8th grade science worksheet: use an mRNA codon chart to classify eight strand changes as silent, missense, nonsense or frameshift. Answer key included. Part of our heredity living things collection. Aligned to NGSS standards.
How do I use this worksheet?
Start with Zoom From Chromosome to Gene to Allele and Label DNA Bases and Copy a Strand to build vocabulary. Then teach mutations, then crosses and pedigrees, and save the DNA profile cases for the end of the unit.
What students will practice
- Students will translate mRNA codons into amino acids using a chart.
- Students will classify mutations as silent, missense, nonsense or frameshift.
- Students will explain why a frameshift is usually more harmful than a missense change.

How a Gene Mutation Affects the Airways

Test Crosses and Expected Offspring Counts

One Base Change and the Sickle Cell Trait


Chromosome Numbers in Mitosis and Meiosis

Find Carriers in a Budgie Feather Pedigree

Mitochondrial DNA Passed Down From Mothers


Label DNA Bases and Copy a Strand

Label the Steps of Inserting a Gene Into Bacteria
Curriculum Links
Next Generation Science Standards
Science · 8th Grade
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Browse the grade, subject, and topic this belongs to.
FAQ
How do I use this heredity worksheet?
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Start with Zoom From Chromosome to Gene to Allele and Label DNA Bases and Copy a Strand to build vocabulary. Then teach mutations, then crosses and pedigrees, and save the DNA profile cases for the end of the unit.
What does this worksheet teach?
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Use an mRNA codon chart to classify eight strand changes as silent, missense, nonsense or frameshift. The directions on the page read: Read the four kinds of mutations and study the codon chart. Then write the amino acid for each practice codon. An answer key is included.
Can I use this heredity worksheet for homeschool or classroom?
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Yes, both. We made it for 8th grade living things, and it works the same at home or at school. At home, a student can work through it alone and then go over it with you, which shows quickly what is solid and what needs another look. In class it works as independent practice, homework or a warm-up, and you can print one copy or a full set.
What is a test cross?
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A test cross mates an organism showing the dominant trait with one showing the recessive trait. If any offspring show the recessive trait, the parent must carry a hidden recessive allele. Test Crosses and Expected Offspring Counts uses purple and green tomato stems to practice this.
How do DNA profiles identify a person or a variety?
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At certain spots, a short piece of DNA repeats a different number of times in different individuals. Each one has two counts at each spot, one from each parent, and samples match only if every count matches. Match STR Repeat Counts in a Missing Bike Case and Use DNA Profiles to Find a Grape Variety's Parents both use this rule.
Why is mitochondrial DNA passed down only from mothers?
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Every mitochondrion in a child comes from the egg, because the sperm's few mitochondria do not survive in the new cell. A mother passes it to all her children, but only her daughters pass it on again. Mitochondrial DNA Passed Down From Mothers traces it through a family tree.
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Worksheet Details
| Grade | 8th Grade |
| Subject | Science |
| Topic | Living Things |
| Standard | MS-LS3-1 |
| Pages | 2 pages |
| Difficulty | Medium |
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How a Gene Mutation Affects the Airways

Test Crosses and Expected Offspring Counts

One Base Change and the Sickle Cell Trait


Chromosome Numbers in Mitosis and Meiosis

Find Carriers in a Budgie Feather Pedigree

Mitochondrial DNA Passed Down From Mothers


Label DNA Bases and Copy a Strand

Label the Steps of Inserting a Gene Into Bacteria